Tuesday, 3/15/2005
8:55 AM - 11:45 AM  Convention Center   33B, Oral

CINF

Informatics and High Throughput Experimentation

Organized by: Mitchell A. Miller
 

8:55 AM

       

 

 Introductory Remarks
   
 

9:00 AM

       

70

 CAMS: A high-throughput compound archive management system
Robert D. Feinstein  
 

9:25 AM

       

71

 SeQuence IDentification: A peptide sequencing algorithm based on gas-phase peptide fragmentation patterns in tandem mass spectrometry
Li Ji Joseph Triscari, Yingying Huang, George Tseng, Shinsheng Yuan, Ljiljana Pasa-Tolic, Mary S Lipton, Richard D. Smith, Vicki H Wysocki
 

9:50 AM

       

72

 Progressable hit identification from HTS data: An integrated informatics solution
Mark A. Hermsmeier  
 

10:15 AM

       

 

 Intermission
   
 

10:30 AM

       

73

 Triple store databases and their role in high throughput, automated, extensible data analysis
Jeremy G Frey Kieron R Taylor, Robert J Gledhill, Jonathan W Essex
 

10:55 AM

 PDF     

74

 Informatics implementation in ExxonMobil Chemical Company
Robert J Wittenbrink Michael E. Lacey, Gregg J. Howsmon, Dave A. Stachelczyk
 

11:20 AM

 PDF     

75

 Designing test plates with maximal information content and diversity for the development of library protocols
Jean E. Patterson Ying Zhang, Andrew Smellie, Daming Li, David S. Hartsough, Libing Yu, Carmen M. Baldino
 

1:45 PM

       

82

 Library design through lead optimization: An application for integrating data and workflow among high-throughput scientists
Louis J. Culot Jr.  
 

2:10 PM

       

83

 Boosting descriptors for similarity searches: feature trees trained by machine learning
Marcus Gastreich Jun Liao, Gerhard Hessler, Stefania Pfeiffer-Marek, Sally Ann Hindle, Manfred Warmuth, Christian Lemmen, Thorsten Naumann, Karl-Heinz Baringhaus
 

2:35 PM

       

84

 Comparison of the effect of false positives on Tanimoto and modified Bayesian similarity
David Rogers  
 

3:00 PM

 PDF     

85

 Design and linkage of compound filters to HTS assay promiscuity
Bradley C. Pearce Michael J Sofia, David A. Stock, Dieter A. Drexler
 

3:25 PM

       

 

 Intermission
   
 

3:40 PM

 PDF     

86

 Fingerprint-based virtual screening using multiple reference structures
Jérôme Hert Peter Willett, David J. Wilton, Pierre Acklin, Kamal Azzaoui, Edgar Jacoby, Ansgar Schuffenhauer
 

4:05 PM

       

87

 Learning from library design
Gregory A. Landrum Julie E. Penzotti, Santosh Putta
 

4:30 PM

       

88

 Using topomer similarity and FlexS with OptDesign to create targeted GPCR libraries
Sun Ch Farhad Soltanshahi, Michael S. Lawless, Richard Hufton, Robert D. Clark