Webinar: HELM for the masses - a notation standard for representing Biologics

Date: September 20, 2013
Time: noon US Eastern Time

Title: HELM for the masses - a notation standard for representing Biologics
Speaker: Roland W. Knispel, ChemAxon

The Hierarchical Editing Language for Macromolecules (HELM), an emerging notation standard, enables the representation of a wide range of biomolecules (e.g. proteins, nucleotides, antibody drug conjugates) through a hierarchical notation that represents complex macromolecules as polymeric structures with support for unnatural components (e.g. unnatural amino acids) and chemical modifications. Created by Pfizer scientists, the Pistoia Alliance formalized the HELM notation as an open standard in early 2013 and publicly released a modified version of previously proprietary software tools to the Open Source community, which now serve as reference implementation of the HELM standard.

This presentation aims to provide a brief overview of the HELM notation and the associated Open Source software tools, followed by a discussion of the prospects of HELM integrating small and large molecule information management systems.

Roland W. Knispel received a Dr. rer. nat. from the Technical University Munich, for work on automation approaches of biological sample preparation for electron microscopy, performed at the Max Planck Institute of Biochemistry in the team of Prof. Wolfgang Baumeister .

With his educational background spanning theory and practice of wet-lab biochemistry, structural biology, computer sciences, and mechanical prototyping, he comfortably operates at the interface between scientific disciplines. 

He currently works as the Technical Project Lead for ChemAxon's future Biologics informatics platform, and he and his team were deeply involved as "Techies" in the HELM project of the Pistoia Alliance.